Tamarindus indica and Dialium guineense are indigenous African fruits trees which contain lots of neutraceutics essentials for their health promoting potentials. The present study investigates the nutritional compositions of T. indica and D. guineense. The study aimed to compare the proximate and mineral composition of these two fruits to evaluate their nutritional benefits. The research analyzed and compared the levels of proximate contents and essential minerals presents in T. indica and D. guineense fruits. The result revealed that T. indica had higher levels of crude fat of about 6.50±0.04, moisture content (26.57±0.03), and crude protein (2.28±0.007), compared to D. guineense which exhibit lower levels of the parameters crude fat (5.45±0.03), Moisture content (0.60±0.10), and crude protein (1.82±0.02), yet revealed no significant difference between the two fruits having a t-value of 0.0124, 0.0020 and 0.0135 respectively. While D. guineense had higher carbohydrate content that reads (88.68±0.01). Mineral analysis showed that T. indica generally had a higher mineral concentrations compared to D. guineense, such as in phosphorus (2196.45±25.70 and 2357.86±31.32), showing a significant difference of 0.0745, potassium (7177.20±71.29 and 5753.47±37.12), and calcium (4530.88±19.19 and 1153.68±6.80), which are vital minerals supporting human energy production and bone health, healthy blood pressure and nerve function and also strengthens bones and teeth respectively. Conversely, D. guineense exhibits higher copper and sodium levels. The study concluded that both fruits have significant nutritional benefits, with T. indica being a valuable source of fiber, protein, and healthy fats, and D. guineense being particularly well-suited for providing readily available energy. The study revealed the abundant nutraceutical potentials of the fruit as natural sources, and the genetic makeup and conservation of the fruit trees should be enhanced.